HMGN1
Function
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).
Post-translational modifications
Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.
Sequence Similarities
Belongs to the HMGN family.
Cellular localization
- Nucleus
- Cytoplasm
- Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.
Alternative names
HMG14, HMGN1, Non-histone chromosomal protein HMG-14, High mobility group nucleosome-binding domain-containing protein 1