HMGN5
Domain
Specifically targeted by its C-terminus to nucleosomes in euchromatin.
Function
Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.
Sequence Similarities
Belongs to the HMGN family.
Tissue Specificity
Ubiquitously expressed.
Cellular localization
- Nucleus
- Associates with nucleosomes in euchromatin and is largely excluded from constitutive heterochromatin.
Alternative names
NSBP1, HMGN5, High mobility group nucleosome-binding domain-containing protein 5, Nucleosome-binding protein 1