Heme Oxygenase 1

The transmembrane domain is necessary for its oligomerization.

Heme oxygenase 1

Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:11121422, PubMed:19556236, PubMed:7703255). Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (PubMed:20055707).

Heme oxygenase 1

(Microbial infection) During SARS-COV-2 infection, promotes SARS-CoV-2 ORF3A-mediated autophagy but is unlikely to be required for ORF3A-mediated induction of reticulophagy.

Heme oxygenase 1 soluble form

Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.

Heme oxygenase 1 deficiency

HMOX1D

A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly.

None

The disease is caused by variants affecting the gene represented in this entry.

A soluble form arises by proteolytic removal of the membrane anchor.

Belongs to the heme oxygenase family.

Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).

• Endoplasmic reticulum membrane
• Single-pass type IV membrane protein
• Cytoplasmic side

HO, HO1, HMOX1, Heme oxygenase 1, HO-1

• entrezGene:3162
• omim:141250
• swissprot:P09601

Proteins

Immuno-oncology

32819Da