HMOX1
GeneName
HMOX1
Summary
HMOX1, also known as HO-1 or heme oxygenase 1, is a 33 kDa enzyme predominantly expressed in various tissues, particularly in response to oxidative stress. It is located in multiple cellular compartments, including the cytosol, endoplasmic reticulum, and mitochondrial outer membrane. HMOX1 catalyses the degradation of heme into biliverdin, carbon monoxide, and free iron, playing a crucial role in heme catabolism and iron homeostasis. This enzyme is involved in several biological processes, such as angiogenesis, cellular responses to environmental stressors, and the regulation of inflammatory responses, highlighting its importance in maintaining cellular health and function.
Importance
HMOX1 is relevant to: - The regulation of oxidative stress responses, which is vital for cellular protection against damage - Angiogenesis and tissue repair processes, particularly in wound healing and inflammation - The modulation of immune responses through its effects on leukocyte migration and cytokine production - The potential therapeutic targeting in conditions such as cardiovascular diseases, cancer, and neurodegenerative disorders due to its protective roles in cellular stress responses and inflammation
Top Products
For researchers investigating HMOX1, we recommend two excellent primary antibodies. The first is the well-cited Anti-Heme Oxygenase 1 antibody [HO-1-1] (ab13248), a trusted choice for Western blotting (WB), immunohistochemistry (IHC), flow cytometry (FC), and ELISA, with 369 citations highlighting its reliability in the field. Additionally, we offer the recombinant antibody, Anti-Heme Oxygenase 1 antibody [EPR1390Y] (ab68477), which has been validated in knockout models and is suitable for WB, immunocytochemistry (ICC), flow cytometry (FC), and immunoprecipitation (IP). With 272 citations, this recombinant antibody provides the batch-to-batch consistency that many researchers seek. Together, these antibodies represent a robust toolkit for studying HMOX1. The Human Heme Oxygenase 1 ELISA Kit, Fluorescent (ab229429) is an excellent option for researchers looking to measure HMOX1 levels in their samples.
Abcam Product Citation Summary
The data indicates a significant focus on the role of HMOX1 in various biological contexts, particularly in response to oxidative stress, inflammation, and injury across multiple species, including humans and rodents. The use of Abcam antibodies in studies involving liver, kidney, and brain tissues highlights the importance of HMOX1 in cellular protection mechanisms and its potential implications in diseases such as neuroinflammation and oxidative stress-related conditions.
Abcam Product Citation Table
Domain
The transmembrane domain is necessary for its oligomerization.
Function
Heme oxygenase 1
Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:11121422, PubMed:19556236, PubMed:7703255). Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (PubMed:20055707).
Heme oxygenase 1
(Microbial infection) During SARS-COV-2 infection, promotes SARS-CoV-2 ORF3A-mediated autophagy but is unlikely to be required for ORF3A-mediated induction of reticulophagy.
Heme oxygenase 1 soluble form
Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.
Involvement in disease
Heme oxygenase 1 deficiency
HMOX1D
A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
A soluble form arises by proteolytic removal of the membrane anchor.
Sequence Similarities
Belongs to the heme oxygenase family.
Tissue Specificity
Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).
Cellular localization
- Endoplasmic reticulum membrane
- Single-pass type IV membrane protein
- Cytoplasmic side
Alternative names
HO, HO1, HMOX1, Heme oxygenase 1, HO-1