HO-2

Heme oxygenase 2

Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.

Heme oxygenase 2 soluble form

Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.

A soluble form arises by proteolytic removal of the membrane anchor.

S-nitrosylated by BLVRB.

Belongs to the heme oxygenase family.

• Microsome membrane
• Single-pass type IV membrane protein
• Cytoplasmic side
• Endoplasmic reticulum membrane
• Single-pass type IV membrane protein
• Cytoplasmic side

HO2, HMOX2, Heme oxygenase 2, HO-2

• entrezGene:3163
• omim:141251
• swissprot:P30519

Proteins

Metabolism

36033Da