HN
Function
Mediates the viral entry into the host cell together with fusion/F protein. Attaches the virus to sialic acid-containing cell receptors and thereby initiates infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion.
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.
Sequence Similarities
Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.
Cellular localization
- Virion membrane
- Single-pass type II membrane protein
- Host cell membrane
- Single-pass type II membrane protein
Alternative names
Hemagglutinin-neuraminidase, HN