Homeobox protein TGIF2

Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.

The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway.

Belongs to the TALE/TGIF homeobox family.

Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.

• Nucleus
• Excluded from nucleoli.

Homeobox protein TGIF2, 5'-TG-3'-interacting factor 2, TGF-beta-induced transcription factor 2, TGFB-induced factor 2, TGIF2

• entrezGene:60436
• omim:607294
• swissprot:Q9GZN2

Proteins

Oncology

25878Da