Homeobox protein TGIF2
Function
Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.
Post-translational modifications
The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway.
Sequence Similarities
Belongs to the TALE/TGIF homeobox family.
Tissue Specificity
Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.
Cellular localization
- Nucleus
- Excluded from nucleoli.
Alternative names
Homeobox protein TGIF2, 5'-TG-3'-interacting factor 2, TGF-beta-induced transcription factor 2, TGFB-induced factor 2, TGIF2