HORMAD1
Function
Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.
Post-translational modifications
Phosphorylated at Ser-377 in a SPO11-dependent manner.
Tissue Specificity
Testis-specific. Over-expressed in carcinomas.
Cellular localization
- Nucleus
- Chromosome
- Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity).
Alternative names
NOHMA, HORMAD1, HORMA domain-containing protein 1, Cancer/testis antigen 46, Newborn ovary HORMA protein, CT46