HOXD10
Developmental stage
Expressed in the developing limb buds.
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Involvement in disease
Vertical talus, congenital
CVT
A rare malformation characterized by vertical orientation of the talus with a rigid dorsal dislocation of the navicular, equinus deformity of the calcaneus, abduction deformity of the forefoot, and contracture of the soft tissues of the hind- and mid-foot. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity with familial occurrence.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the Abd-B homeobox family.
Tissue Specificity
Strongly expressed in the adult male and female urogenital tracts.
Cellular localization
- Nucleus
Alternative names
HOX4D, HOX4E, HOXD10, Homeobox protein Hox-D10, Homeobox protein Hox-4D, Homeobox protein Hox-4E