HRNR
Function
Component of the epidermal cornified cell envelopes.
Post-translational modifications
Processed during the process of epidermal differentiation.
Forms covalent cross-links mediated by transglutaminase TGM3, between glutamine and the epsilon-amino group of lysine residues (in vitro).
Sequence Similarities
Belongs to the S100-fused protein family.
In the N-terminal section; belongs to the S-100 family.
Tissue Specificity
Expressed in cornified epidermis, psoriatic and regenerating skin after wounding. Found in the upper granular layer and in the entire cornified layer of epidermis.
Cellular localization
- Cytoplasmic granule
- Found in keratohyalin granules in the granular cells of the epidermis.
Alternative names
S100A18, HRNR, Hornerin