hry

Domain

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).

The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho (gro), a transcriptional corepressor recruited to specific target DNA by Hairy-related proteins.

Function

Pair-rule protein that regulates embryonic segmentation and adult bristle patterning. Transcriptional repressor of genes that require a bHLH protein for their transcription (e.g. ftz).

Post-translational modifications

Ubiquitinated by Topors.

Cellular localization

• Nucleus

Alternative names

h, CG6494, hry, Protein hairy

Database links

swissprot:P14003 swissprot:Q960W5 swissprot:Q95NH3 swissprot:Q95NU9 entrezGene:38995