HSD17B13
Function
Plays a pivotal role in hepatic lipid metabolism (PubMed:29562163). In vitro, it catalyzes the oxidation of a variety of lipid substrates, including 17beta-estradiol, retinol, retinal, and leukotriene B4 (PubMed:29562163, PubMed:30415504, PubMed:32973038).
Isoform 2
Has retinol/retinal dehydrogenase activity in vitro.
Isoform 1
Does not have retinol/retinal dehydrogenase activity in vitro.
Sequence Similarities
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Tissue Specificity
Highly expressed in the liver (PubMed:29562163). Also detected in ovary, bone marrow, kidney, brain, lung, skeletal muscle, bladder and testis.
Cellular localization
- Isoform 2
- Lipid droplet
- Endoplasmic reticulum
- Redistributed from the endoplasmic reticulum to lipids droplets in the cell upon induction of lipids droplet formation.
- Isoform 1
- Cytoplasm
- Does not localize to lipid droplets.
Alternative names
SCDR9, SDR16C3, HMFN0376, UNQ497/PRO1014, HSD17B13, 17-beta-hydroxysteroid dehydrogenase 13, 17-beta-HSD 13, Hepatic retinol/retinal dehydrogenase, Short chain dehydrogenase/reductase family 16C member 3, Short-chain dehydrogenase/reductase 9