Hspa9
Developmental stage
Expressed in embryonic fibroblasts (at protein level).
Function
Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis (PubMed:26702583). Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (By similarity). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823). May play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (By similarity). May play a role in the control of cell proliferation and cellular aging (By similarity) (PubMed:21123823, PubMed:26702583, PubMed:8454632). Molecular adapter that regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (PubMed:29907098).
Sequence Similarities
Belongs to the heat shock protein 70 family.
Cellular localization
- Mitochondrion
- Nucleus
- Nucleolus
- Cytoplasm
- Mitochondrion matrix
- Found in a complex with HSPA9 and VDAC1 at the endoplasmic reticulum-mitochondria contact sites.
Alternative names
Grp75, Hsp74, Hspa9a, Hspa9, 75 kDa glucose-regulated protein, Heat shock 70 kDa protein 9, Mortalin, Peptide-binding protein 74, p66 MOT, GRP-75, PBP74