HSPB6 phospho S16
Function
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity.
Post-translational modifications
The N-terminus is blocked.
Phosphorylated at Ser-16 by PKA and probably PKD1K; required to protect cardiomyocytes from apoptosis.
Sequence Similarities
Belongs to the small heat shock protein (HSP20) family.
Cellular localization
- Cytoplasm
- Nucleus
- Secreted
- Translocates to nuclear foci during heat shock.
Alternative names
Heat shock protein beta-6, HspB6, Heat shock 20 kDa-like protein p20, Heat shock protein family B member 6, HSPB6