Hspg2
Function
Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development (By similarity).
Endorepellin
Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6 (By similarity).
LG3 peptide
Has anti-angiogenic properties that require binding of calcium ions for full activity.
Post-translational modifications
Proteolytic processing produces the C-terminal angiogenic peptide, endorepellin. This peptide can be further processed to produce the LG3 peptide (By similarity).
O-glycosylated. Contains three heparan sulfate chains. Also contains chondroitin sulfate.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
- Basement membrane
- Secreted
Alternative names
Basement membrane-specific heparan sulfate proteoglycan core protein, HSPG, Hspg2