HSPH1

Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).

Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.

Belongs to the heat shock protein 70 family.

Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.

• Cytoplasm

HSP105, HSP110, KIAA0201, HSPH1, Heat shock protein 105 kDa, Antigen NY-CO-25, Heat shock 110 kDa protein, Heat shock protein family H member 1

• entrezGene:10808
• omim:610703
• swissprot:Q92598

Proteins

Immunology & Infectious Disease

96865Da