Htr1a
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:2140514, PubMed:2156831). Also functions as a receptor for various drugs and psychoactive substances (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (By similarity). Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes (By similarity).
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.
Tissue Specificity
Detected in hypothalamus, mesencephalon, amygdala, medulla, thalamus, septum and hippocampus.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Cell projection
- Dendrite
Alternative names
5ht1a, Htr1a, 5-hydroxytryptamine receptor 1A, 5-HT-1A, 5-HT1A, Serotonin receptor 1A