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HTR7

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Tissue specificity

Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in terms of expression.

Cellular localization

  • Cell membrane
  • Multi-pass membrane protein

Alternative names

  • 5-hydroxytryptamine receptor 7
  • 5-HT-7
  • 5-HT7
  • 5-HT-X
  • Serotonin receptor 7
  • HTR7

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

53555Da