HTR7
Domain
Specificity for G(s) G alpha proteins is determined by the length of transmembrane regions 5 and 6 (TM5 and TM6).
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35714614, PubMed:8226867). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:35714614, PubMed:8226867). HTR7 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:35714614).
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Isoform A
Predominant isoform in spleen, caudate and hippocampus.
Isoform B
Expressed at lower levels.
Isoform D
Minor isoform in terms of expression.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
5-hydroxytryptamine receptor 7, 5-HT-7, 5-HT7, 5-HT-X, Serotonin receptor 7, HTR7