Skip to main content

HTR7

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. This receptor is implicated in the regulation of mammalian circadian rhythms.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Tissue specificity

Thalamus, hypothalamus, and the hippocampal rudiments.

Cellular localization

  • Cell membrane
  • Multi-pass membrane protein

Alternative names

  • 5-hydroxytryptamine receptor 7
  • 5-HT-7
  • 5-HT7
  • 5-HT-X
  • GPRFO
  • Serotonin receptor 7

Target type

Proteins

Molecular weight

49837Da