Hyaluronan synthase 3
Function
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis.
Pathway
Glycan biosynthesis; hyaluronan biosynthesis.
Post-translational modifications
O-GlcNAcylation increases the hyaluronan synthase activity, HAS3 stability and its plasma membrane residence. The concentration of UDP-GlcNAc controls the level of O-GlcNAc modification.
Sequence Similarities
Belongs to the NodC/HAS family.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Golgi apparatus membrane
- Multi-pass membrane protein
- Golgi apparatus
- trans-Golgi network membrane
- Multi-pass membrane protein
- Early endosome
- Travels from endoplasmic reticulum (ER), Golgi to plasma membrane (PubMed:26883802). Actives only when present in plasma membrane (By similarity). O-GlcNAcylation controls its membrane localization (PubMed:26883802). A rapid recycling of HAS3 between plasma membrane and endosomes is controlled by the cytosolic levels of UDP-GlcUA and UDP-GlcNAc (PubMed:26883802).
Alternative names
Hyaluronan synthase 3, Hyaluronate synthase 3, Hyaluronic acid synthase 3, HA synthase 3, HAS3