Iapp
Domain
The mature protein is largely unstructured in the absence of a cognate ligand, but contrary to the human protein, it does not easily form fibrillar aggregates.
Function
Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis (By similarity). Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes. Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs (By similarity).
Sequence Similarities
Belongs to the calcitonin family.
Cellular localization
- Secreted
Alternative names
Islet amyloid polypeptide, IAPP, Amylin, Diabetes-associated peptide, DAP, Iapp