ICAM1

Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.

(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins.

(Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins.

(Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.

Post-translational modifications

Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.

Sequence similarities

Belongs to the immunoglobulin superfamily. ICAM family.

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

• Intercellular adhesion molecule 1
• ICAM-1
• Major group rhinovirus receptor
• ICAM1

Database links

• entrezGene:3383
• omim:147840
• swissprot:P05362

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

• Cardiovascular
• Immuno-oncology
• Neuroscience

Molecular weight

57825Da