ICAM1
GeneName
ICAM1
Summary
ICAM1, also known as intercellular adhesion molecule 1, CD54, is a 58 kDa glycoprotein expressed on the surface of various cell types, including endothelial cells, leukocytes, and some epithelial cells. It is primarily localised to the plasma membrane and plays a crucial role in cell adhesion processes, facilitating heterophilic interactions between leukocytes and endothelial cells. ICAM1 acts as a receptor for integrins and is involved in the establishment of the endothelial barrier, leukocyte migration, and T cell activation. Additionally, it serves as a receptor for certain viruses, contributing to their entry into host cells.
Importance
ICAM1 is relevant to: - Immune response regulation through its role in leukocyte adhesion and migration, influencing inflammatory processes. - Endothelial function and integrity, particularly in the context of vascular diseases and conditions affecting blood flow. - Pathogenesis of viral infections, as it serves as a receptor for viral entry, impacting infection dynamics. - Neurodegenerative diseases, where its involvement in cellular responses to amyloid-beta suggests a role in neuroinflammation.
Top Products
For researchers investigating ICAM1, we recommend two excellent primary antibodies. The first is the well-cited Anti-ICAM1 antibody [MEM-111] (ab2213), which has garnered 90 citations, reflecting its reliability in Western blotting (WB) and flow cytometry (FC). This monoclonal antibody is a trusted choice for those requiring robust performance in these applications. Additionally, we offer the recombinant antibody, Anti-ICAM1 antibody [EP1442Y] (ab53013), which has been validated for use in WB and immunohistochemistry (IHC). With 68 citations, this recombinant product ensures batch-to-batch consistency, making it an excellent option for researchers seeking dependable ICAM1 detection across various experimental setups. The Human ICAM1 ELISA Kit, Fluorescent (ab229383), with 2 citations, offers a reliable option for researchers looking to measure ICAM1 levels in their samples.
Abcam Product Citation Summary
The data indicates that ICAM1 is being extensively studied in various contexts, particularly in relation to inflammation, apoptosis, and cancer. The use of Abcam antibodies in human and rat samples highlights the relevance of ICAM1 in both human diseases such as acute respiratory distress syndrome (ARDS) and pancreatic ductal adenocarcinoma, as well as in basic research on cell adhesion mechanisms.
Abcam Product Citation Table
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.
(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins.
(Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins.
(Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.
Post-translational modifications
Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
Sequence Similarities
Belongs to the immunoglobulin superfamily. ICAM family.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
CD54, Intercellular adhesion molecule 1, ICAM-1, Major group rhinovirus receptor, ICAM1
Database links
swissprot:P05362 omim:147840 entrezGene:3383
Other research areas
- Cardiovascular
- Immuno-oncology
- Neuroscience