Icam1

Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity).

Post-translational modifications

Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.

Sequence Similarities

Belongs to the immunoglobulin superfamily. ICAM family.

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

CD54, Icam-1, Icam1, Intercellular adhesion molecule 1, ICAM-1

Database links

swissprot:Q00238 entrezGene:25464

Other research areas

• Cardiovascular
• Immuno-oncology
• Neuroscience