ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity).
Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
Belongs to the immunoglobulin superfamily. ICAM family.
Expressed at low level on a subpopulation of lymphocytes, macrophages, and endothelial cells, but is strongly induced on these cells, and on fibroblasts and epithelial cells.
CD54, Icam-1, Icam1, Intercellular adhesion molecule 1, ICAM-1, MALA-2, MyD10
Proteins
Immunology & Infectious Disease
58844Da
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