Icam1

Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity).

Post-translational modifications

Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.

Sequence Similarities

Belongs to the immunoglobulin superfamily. ICAM family.

Tissue Specificity

Expressed at low level on a subpopulation of lymphocytes, macrophages, and endothelial cells, but is strongly induced on these cells, and on fibroblasts and epithelial cells.

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

CD54, Icam-1, Icam1, Intercellular adhesion molecule 1, ICAM-1, MALA-2, MyD10

Database links

swissprot:P13597 entrezGene:15894

Other research areas

• Cardiovascular
• Immuno-oncology
• Neuroscience