ICAM2

Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

Sequence similarities

Belongs to the immunoglobulin superfamily. ICAM family.

Tissue specificity

Expressed in endothelial cells and leukocytes. High levels found in lung.

Cellular localization

• Membrane
• Single-pass type I membrane protein
• Cell projection
• Microvillus
• Co-localizes with RDX, EZR and MSN in microvilli.

Alternative names

• Intercellular adhesion molecule 2
• ICAM-2
• Lymphocyte function-associated AG-1 counter-receptor
• Icam2
• Icam-2

Database links

• entrezGene:15896
• swissprot:P35330

Target type

Proteins

Molecular weight

31390Da