ICAM2

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

Belongs to the immunoglobulin superfamily. ICAM family.

Expressed in endothelial cells and leukocytes. High levels found in lung.

• Membrane
• Single-pass type I membrane protein
• Cell projection
• Microvillus
• Co-localizes with RDX, EZR and MSN in microvilli.

CD102, Icam-2, Icam2, Intercellular adhesion molecule 2, ICAM-2, Lymphocyte function-associated AG-1 counter-receptor

• entrezGene:15896
• swissprot:P35330

Proteins

Developmental Biology

31390Da