ICAM2
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
Sequence Similarities
Belongs to the immunoglobulin superfamily. ICAM family.
Cellular localization
- Membrane
- Single-pass type I membrane protein
- Cell projection
- Microvillus
- Co-localizes with RDX, EZR and MSN in microvilli.
Alternative names
CD102, Intercellular adhesion molecule 2, ICAM-2, ICAM2