ICAM2

Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

Sequence similarities

Belongs to the immunoglobulin superfamily. ICAM family.

Cellular localization

• Membrane
• Single-pass type I membrane protein
• Cell projection
• Microvillus
• Co-localizes with RDX, EZR and MSN in microvilli.

Alternative names

• Intercellular adhesion molecule 2
• ICAM-2
• ICAM2

Database links

• entrezGene:3384
• omim:146630
• swissprot:P13598

Target type

Proteins

Primary research area

Developmental Biology

Molecular weight

30654Da