ICAM3
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Post-translational modifications
Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.
N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains.
Sequence Similarities
Belongs to the immunoglobulin superfamily. ICAM family.
Tissue Specificity
Leukocytes.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
CD50, Intercellular adhesion molecule 3, ICAM-3, CDw50, ICAM-R, ICAM3