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Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).

Post-translational modifications

Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.

N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains.

Sequence similarities

Belongs to the immunoglobulin superfamily. ICAM family.

Tissue specificity

Leukocytes.

Cellular localization

  • Membrane
  • Single-pass type I membrane protein

Alternative names

Intercellular adhesion molecule 3, ICAM-3, CDw50, ICAM-R, ICAM3

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Molecular weight

59541Da

We found 22 products in 4 categories

Primary Antibodies

Target

Reactive species

Assay Kits

Target

Reactive species

Detection method

Proteins & Peptides

Target

Species of origin

Nature