ICAM4

Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.

Post-translational modifications

N- and O-glycosylated.

Sequence similarities

Belongs to the immunoglobulin superfamily. ICAM family.

Tissue specificity

Erythrocytes.

Cellular localization

• Isoform Long
• Cell membrane
• Single-pass type I membrane protein
• Isoform Short
• Secreted
• Cell membrane
• Single-pass type I membrane protein

Alternative names

• Intercellular adhesion molecule 4
• ICAM-4
• Landsteiner-Wiener blood group glycoprotein
• LW blood group protein
• LW
• ICAM4

Database links

• entrezGene:3386
• omim:614088
• swissprot:Q14773

Target type

Proteins

Primary research area

Oncology

Molecular weight

29265Da