Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion (PubMed:11007762, PubMed:11023515, PubMed:30498080). Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP) (PubMed:30498080).
Immunodeficiency 119
IMD119
An autosomal recessive immunologic disorder characterized by childhood-onset of recurrent respiratory tract infections, susceptibility to chronic DNA-based viral infections, hypogammaglobulinemia, and panlymphopenia.
None
The disease may be caused by variants affecting the gene represented in this entry.
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Expressed on peripheral blood B-cells and monocytes, as well as on monocyte-derived dendritic cells (at protein level).
Isoform 1
Widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil).
Isoform 2
Detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.
Proteins
Immuno-oncology
33349Da
We found 30 products in 5 categories
ab244428
ab272762
Anti-ICOS Ligand/ICOSL antibody [EPR20240-230] - BSA and Azide free (Detector)
ab272761
Anti-ICOS Ligand/ICOSL antibody [EPR20240-231] - BSA and Azide free (Capture)