ID1

Developmental stage

Expression correlates with proliferation in some types of cells.

Function

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).

Cellular localization

• Cytoplasm
• Nucleus

Alternative names

• DNA-binding protein inhibitor ID-1
• Class B basic helix-loop-helix protein 24
• Inhibitor of DNA binding 1
• Inhibitor of differentiation 1
• bHLHb24
• ID1
• BHLHB24
• ID

Database links

• entrezGene:3397
• omim:600349
• swissprot:P41134

Target type

Proteins

Primary research area

Epigenetics

Other research areas

• Oncology

Molecular weight

16133Da