IFFO1
Function
Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) (PubMed:31548606). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that relocalizes to the DSB sites in a XRCC4-dependent manner and promotes the immobilization of the broken ends, thereby preventing chromosome translocation (PubMed:31548606). Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites (PubMed:31548606).
Sequence Similarities
Belongs to the intermediate filament family.
Tissue Specificity
Ubiquitously expressed.
Cellular localization
- Nucleus
- Nucleus
- Nucleoplasm
- Nucleus inner membrane
- Nucleus matrix
- Mainly soluble, the remaining is localized in the nuclear matrix (PubMed:31548606). Localized at double-strand break (DSB) sites near the lamina and nuclear matrix structures (PubMed:31548606).
Alternative names
IFFO, IFFO1, Non-homologous end joining factor IFFO1, NHEJ factor IFFO1, Intermediate filament family orphan 1, Tumor antigen HOM-TES-103