IFT88
Function
Positively regulates primary cilium biogenesis (PubMed:17604723). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.
Tissue Specificity
Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Centriole
- Cell projection
- Cilium
- Cytoplasm
- Cytoskeleton
- Cilium basal body
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Cytoplasm
- Cell projection
- Cilium
- Flagellum
- Cytoplasm
- Cytoskeleton
- Colocalizes with ENTR1 and gamma-tubulin at the basal body of primary cilia (PubMed:27767179). Colocalizes with ENTR1 and pericentrin at the centrosome (PubMed:27767179). In sperm cells, localizes to the manchette, head-tail coupling apparatus and flagellum (By similarity).
Alternative names
TG737, TTC10, IFT88, Intraflagellar transport protein 88 homolog, Recessive polycystic kidney disease protein Tg737 homolog, Tetratricopeptide repeat protein 10, TPR repeat protein 10