IGF1
GeneName
IGF1
Summary
IGF1, also known as insulin-like growth factor I or IGF-1, is a 22kDa peptide hormone predominantly secreted by the liver and plays a crucial role in growth and development. It is involved in various biological processes including cell growth, proliferation, and differentiation, and is known for its binding to the insulin-like growth factor receptor (IGF1R) and insulin receptors. IGF1 is found in the extracellular region and is associated with several complexes such as the insulin-like growth factor binding protein complex and the integrin-IGF-1-IGF1R complex. This hormone is essential for processes like muscle hypertrophy, bone mineralization, and vascular remodeling.
Importance
IGF1 is relevant to: - Growth and development regulation, particularly in muscle and bone tissues - Cancer research due to its role in cell proliferation and differentiation, which can influence tumour growth - Metabolic diseases, as it is involved in the cellular response to insulin and glucose - Neurodegenerative diseases, given its involvement in cellular responses to amyloid-beta - Cardiovascular health, through its impact on blood vessel remodeling and cardiac muscle development
Top Products
For researchers investigating IGF1, we recommend two primary antibodies that stand out for their performance. The first is the well-cited polyclonal antibody, Anti-IGF1 antibody (ab106836), which has garnered 20 citations, reflecting its reliability in the field. This antibody is particularly effective for Western blotting (WB) and immunocytochemistry (ICC), making it a versatile choice for various experimental needs. Additionally, we offer the recombinant antibody, Anti-IGF1 antibody [EPR5099] (ab134140). This monoclonal antibody is validated for use in Western blotting (WB) and provides the consistency that comes with recombinant products. With 4 citations, it is gaining traction among researchers looking for dependable IGF1 detection. Together, these antibodies provide robust options for studying IGF1 in your research. The Recombinant human IGF1 protein (Active) ELISA Kit (ab270062), supported by 9 citations, is an excellent option for researchers looking to accurately measure IGF1 levels in their samples.
Abcam Product Citation Summary
The data indicates that IGF1 is being studied across various contexts, including neuronal responses, ovarian tissue transplantation, and metabolic pathways. The use of multiple applications such as Western blotting and immunohistochemistry highlights the importance of IGF1 in different biological processes, particularly in mouse and human models.
Abcam Product Citation Table
Function
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:19578119, PubMed:22351760, PubMed:23243309, PubMed:23696648). As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity).
Involvement in disease
Insulin-like growth factor I deficiency
IGF1D
An autosomal recessive disorder characterized by growth retardation, sensorineural deafness and intellectual disability.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the insulin family.
Cellular localization
- Secreted
Alternative names
IBP1, IGF-1, IGF1, Insulin-like growth factor 1, Insulin-like growth factor I, Mechano growth factor, Somatomedin-C, IGF-I, MGF
Database links
swissprot:P05019 entrezGene:3479 swissprot:Q14620 swissprot:P01343 omim:147440
Other research areas
- Cardiovascular