JavaScript is disabled in your browser. Please enable JavaScript to view this website.

IGFALS

Function

Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.

Involvement in disease

Acid-labile subunit deficiency

ACLSD

A disorder characterized by severely reduced serum IGF-I and IGFBP-3 concentrations and mild growth retardation. Pubertal delay in boys and insulin insensitivity are common findings.

None

The disease is caused by variants affecting the gene represented in this entry.

Tissue Specificity

Plasma.

Cellular localization

Alternative names

ALS, IGFALS, Insulin-like growth factor-binding protein complex acid labile subunit

swissprot:P35858 omim:601489 entrezGene:3483