Igfbp3
Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Promotes testicular germ cell apoptosis.
Post-translational modifications
Phosphorylated by FAM20C in the extracellular medium.
Cellular localization
- Secreted
Alternative names
Igfbp-3, Igfbp3, Insulin-like growth factor-binding protein 3, IBP-3, IGF-binding protein 3, IGFBP-3