Igfbp6
Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration.
Post-translational modifications
O-glycosylated.
Cellular localization
- Secreted
Alternative names
Igfbp-6, Igfbp6, Insulin-like growth factor-binding protein 6, IBP-6, IGF-binding protein 6, IGFBP-6