IGFBP6

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration (PubMed:24003225).

Post-translational modifications

O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid.

Cellular localization

• Secreted

Alternative names

• Insulin-like growth factor-binding protein 6
• IBP-6
• IGF-binding protein 6
• IGFBP-6
• IBP6
• IGFBP6

Database links

• entrezGene:3489
• omim:146735
• swissprot:P24592

Target type

Proteins

Molecular weight

25322Da