IgGFc-binding protein
Domain
The N-terminal IgGFc-binding region is primate-specific.
Function
May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa.
Tissue Specificity
Mainly expressed in placenta and colon epithelium. Expressed in thyroid, and down-regulated in thyroid carcinomas. Present in serum, with higher levels in patients with various autoimmune diseases (at protein level).
Cellular localization
- Secreted
Alternative names
IgGFc-binding protein, Fcgamma-binding protein antigen, FcgammaBP, FCGBP