Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.
Belongs to the Ikaros C2H2-type zinc-finger protein family.
Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.
Proteins
58023Da
We found 12 products in 2 categories
ab88513
ab134288
ab132618