C2H2-type 5 and C2H2-type 6 mediate homodimerization and heterodimerization.
Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
Immunodeficiency 84
IMD84
An autosomal recessive immunologic disorder characterized by recurrent sinopulmonary infections from childhood associated with low levels of B cells and impaired early B-cell development. There may also be variable T-cell abnormalities. Patients have increased susceptibility to infection with Epstein-Barr virus and a propensity for the development of lymphoma in adulthood.
None
The disease is caused by variants affecting the gene represented in this entry.
Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.
Belongs to the Ikaros C2H2-type zinc-finger protein family.
Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.
ZNFN1A3, IKZF3, Zinc finger protein Aiolos, Ikaros family zinc finger protein 3
Proteins
58023Da
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