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IL13RA1

Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Function

Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.

Sequence similarities

Belongs to the type I cytokine receptor family. Type 5 subfamily.

Tissue specificity

Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.

Cellular localization

  • Membrane
  • Single-pass type I membrane protein

Alternative names

  • Interleukin-13 receptor subunit alpha-1
  • IL-13 receptor subunit alpha-1
  • IL-13R subunit alpha-1
  • IL-13R-alpha-1
  • IL-13RA1
  • Cancer/testis antigen 19
  • CT19
  • IL13RA1
  • IL13R
  • IL13RA

Target type

Proteins

Molecular weight

48760Da