IL13RA2
Domain
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The cytoplasmic domain functions as an inhibitor of IL-4 or IL-13-dependent activation of the Jak-Stat pathway (PubMed:11861389).
Function
Cell surface receptor that plays a role in the regulation of IL-13-mediated responses (PubMed:11861389, PubMed:17030238). Functions as a decoy receptor that inhibits IL-13- and IL-4-mediated signal transduction via the JAK-STAT pathway and thereby modulates immune responses and inflammation (PubMed:11861389, PubMed:17030238). Serves as a functional signaling receptor for IL-13 in an alternative pathway involving AP-1 ultimately leading to the production of TGFB1 (PubMed:16327802).
Post-translational modifications
Cleaved by MMP8 leading to a soluble form that is also able to interact with IL13.
Sequence Similarities
Belongs to the type I cytokine receptor family. Type 5 subfamily.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
CD213a2, IL13R, IL13RA2, Interleukin-13 receptor subunit alpha-2, IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, IL-13R-alpha-2, IL-13RA2, Interleukin-13-binding protein