Il15ra
Function
High-affinity receptor for interleukin-15 (PubMed:17947230). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (PubMed:17947230). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (By similarity). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (By similarity).
Post-translational modifications
N-glycosylated and O-glycosylated.
A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor (By similarity). It also binds IL15 and thus interferes with IL15 binding to the membrane receptor (By similarity).
Tissue Specificity
Widely expressed.
Cellular localization
- Membrane
- Single-pass type I membrane protein
- Nucleus membrane
- Single-pass type I membrane protein
- Cell surface
- Soluble interleukin-15 receptor subunit alpha
- Secreted
- Extracellular space
Alternative names
CD215, Interleukin-15 receptor subunit alpha, IL-15 receptor subunit alpha, IL-15R-alpha, IL-15RA