IL18R1

The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.

Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (By similarity). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (PubMed:26099046).

Belongs to the interleukin-1 receptor family.

• Membrane
• Single-pass type I membrane protein

CD218a, Interleukin-18 receptor 1, IL-18R-1, IL-18R1, CD218 antigen-like family member A, IL1 receptor-related protein, Interleukin-18 receptor alpha, IL-1Rrp, IL1R-rp, IL-18R-alpha, IL-18Ralpha, Il18r1

• entrezGene:16182
• swissprot:Q61098

Proteins

Immunology & Infectious Disease

61601Da