IL1F10
Function
Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.
Sequence Similarities
Belongs to the IL-1 family.
Tissue Specificity
Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil.
Cellular localization
- Cytoplasm
- Secreted
- The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
Alternative names
FIL1T, IL1HY2, IL38, FKSG75, UNQ6119/PRO20041, IL1F10, Interleukin-1 family member 10, IL-1F10, Family of interleukin 1-theta, Interleukin-1 HY2, Interleukin-1 theta, Interleukin-38, FIL1 theta, IL-1HY2, IL-1 theta, IL-38