IL1RAPL2
Domain
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Sequence Similarities
Belongs to the interleukin-1 receptor family.
Tissue Specificity
Detected at low levels in fetal and adult brain, in particular in the frontal lobe, temporal lobe and cerebellum. Detected at very low levels in skin, liver, fetal ovary and in placenta.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
IL1R9, IL1RAPL2, X-linked interleukin-1 receptor accessory protein-like 2, IL-1 receptor accessory protein-like 2, IL-1-RAPL-2, IL-1RAPL-2, IL1RAPL-2, IL1RAPL-2-related protein, Interleukin-1 receptor 9, Three immunoglobulin domain-containing IL-1 receptor-related 1, IL-1R-9, IL-1R9, TIGIRR-1