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IL1RL1

OverviewProducts

Domain

The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.

Function

Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.

Isoform B

Inhibits IL-33 signaling.

Sequence similarities

Belongs to the interleukin-1 receptor family.

Tissue specificity

Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver.

Cellular localization

  • Isoform C
  • Cell membrane
  • Isoform B
  • Secreted
  • Cell membrane
  • Single-pass type I membrane protein

Alternative names

  • Interleukin-1 receptor-like 1
  • Protein ST2
  • T1
  • ST2
  • IL1RL1
  • DER4

Database links

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

  • Immuno-oncology

Molecular weight

63358Da