Il1rn

Function

Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.

Sequence similarities

Belongs to the IL-1 family.

Cellular localization

• Isoform 1
• Secreted
• Isoform 2
• Cytoplasm

Alternative names

• Interleukin-1 receptor antagonist protein
• IL-1RN
• IL-1ra
• IRAP
• IL1 inhibitor
• Il1rn
• Il-1ra

Database links

• entrezGene:16181
• swissprot:P25085

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Molecular weight

20274Da