IL1RN
GeneName
IL1RN
Summary
IL1RN, also known as IL-1RA, is a 20kDa secreted protein that functions as an antagonist to interleukin-1 (IL-1) receptors. It is primarily expressed in the cytoplasm and can be found in various cellular compartments including the extracellular space and exosomes. IL1RN plays a crucial role in modulating inflammatory responses by binding to IL-1 receptors, thereby inhibiting IL-1-mediated signalling pathways. This regulation is vital for maintaining immune homeostasis and preventing excessive inflammation.
Importance
IL1RN is relevant to: - The regulation of inflammatory responses, particularly in conditions such as rheumatoid arthritis and other autoimmune diseases. - The acute-phase response, which is critical during infections and tissue injury. - The modulation of insulin secretion, linking it to metabolic processes and potential implications in diabetes. - The negative regulation of cell-cell adhesion, which may influence processes such as tissue remodelling and repair.
Top Products
For researchers investigating IL1RN, we highly recommend the top-selling recombinant antibody, Anti-IL-1RA antibody [EPR6483] (ab124962). This antibody has been validated in knockout models, ensuring its reliability in research applications. It is particularly effective for Western blotting (WB), making it an excellent choice for those looking to study IL1RN with confidence. With 40 citations, this antibody is well-regarded in the scientific community, reflecting its trusted performance in various studies. The Human IL-1ra ELISA Kit, Fluorescent (ab229435) is an excellent option for researchers looking to measure IL-1ra levels in their samples.
Abcam Product Citation Summary
The data indicates that the IL1RN antibody (ab124962) was utilised in Western blotting to study cytokine regulation in House mice. This suggests a focus on the role of IL1RN in immune responses and inflammation.
Abcam Product Citation Table
Function
Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
Involvement in disease
Microvascular complications of diabetes 4
MVCD4
Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
None
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Chronic recurrent multifocal osteomyelitis 2, with periostitis and pustulosis
CRMO2
An autosomal recessive, autoinflammatory disease of skin and bone resulting in sterile multifocal osteomyelitis, periostitis, and pustulosis from birth. The term autoinflammatory disease describes a group of disorders characterized by attacks of seemingly unprovoked inflammation without significant levels of autoantibodies and autoreactive T-cells.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the IL-1 family.
Tissue Specificity
The intracellular form of IL1RN is predominantly expressed in epithelial cells.
Cellular localization
- Isoform 1
- Secreted
- Isoform 2
- Cytoplasm
- Isoform 3
- Cytoplasm
- Isoform 4
- Cytoplasm
Alternative names
IL1F3, IL1RA, IL1RN, Interleukin-1 receptor antagonist protein, IL-1RN, IL-1ra, IRAP, ICIL-1RA, IL1 inhibitor