Il21r

Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Function

This is a receptor for interleukin-21.

Post-translational modifications

C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 4 subfamily.

Tissue Specificity

Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

CD360, Nilr, Il21r, Interleukin-21 receptor, IL-21 receptor, IL-21R, Lymphocyte receptor beta, Novel cytokine receptor 8, Novel interleukin receptor, LR-beta, NR8

Database links

swissprot:Q9JHX3 entrezGene:60504

Other research areas

• Immuno-oncology