IL23A
GeneName
IL23A
Summary
IL23A, also known as IL-23 or IL-23p19, is a 21 kDa cytokine that plays a pivotal role in the immune response. It is primarily secreted and is found in the extracellular region, where it forms part of the interleukin-23 complex. IL23A is crucial for mediating cell surface receptor signalling pathways, particularly through the JAK-STAT pathway, and is involved in various biological processes such as the defence response to Gram-negative bacteria and viruses, as well as the regulation of T cell proliferation and differentiation. This cytokine is expressed in immune cells and contributes to inflammatory responses and the innate immune response.
Importance
IL23A is relevant to: - The pathogenesis of autoimmune diseases like psoriasis and inflammatory bowel disease due to its role in promoting T-helper 17 cell responses. - Cancer immunology, as it can influence tumour microenvironments and T cell activity. - Infectious diseases, where it helps orchestrate the immune response against pathogens. - Therapeutic targeting, as inhibitors of IL-23 signalling are being developed for treating chronic inflammatory conditions.
Top Products
For researchers investigating IL23A, we recommend two primary antibodies that stand out for their reliability and performance. The first is the well-cited polyclonal antibody, Anti-IL-23 antibody (ab45420), which has garnered 41 citations, reflecting its strong reputation in the field. This antibody is versatile, suitable for immunohistochemistry (IHC), western blotting (WB), and immunocytochemistry (ICC), making it an excellent choice for various experimental setups.Additionally, we offer the recombinant antibody, Anti-IL-23 antibody [EPR5585(N)] - C-terminal (ab190356). This monoclonal antibody has been validated for use in western blotting (WB) and is a great option for those seeking the consistency that recombinant antibodies provide. With 7 citations, it is gaining traction among researchers. Together, these antibodies provide robust tools for studying IL23A effectively. "The Human IL-23 ELISA Kit (ab221837), supported by 4 citations, is an excellent option for researchers looking to accurately measure IL-23 levels in their samples."
Abcam Product Citation Summary
The data indicates that the IL23A antibody (ab45420) has been effectively used in Western blotting to study IL23A expression in human tissues affected by Crohn's disease, specifically in intestinal mucosa and mesenteric adipose tissue. This suggests a potential role of IL23A in the pathology of Crohn's disease.
Abcam Product Citation Table
Developmental stage
Expressed by newborns dendritic cells.
Function
Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity (PubMed:11114383). Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4 (PubMed:29287995, PubMed:32474165, PubMed:33606986). This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A (PubMed:12023369). In turn, participates in the early and effective intracellular bacterial clearance (PubMed:32474165). Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells (PubMed:17676044).
Sequence Similarities
Belongs to the IL-6 superfamily.
Tissue Specificity
Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
Cellular localization
- Secreted
- Secreted upon association with IL12B.
Alternative names
SGRF, UNQ2498/PRO5798, IL23A, Interleukin-23 subunit alpha, IL-23 subunit alpha, IL-23-A, Interleukin-23 subunit p19, IL-23p19
Database links
swissprot:Q9NPF7 entrezGene:3593 entrezGene:51561 swissprot:P29460 omim:605580 omim:161561
Other research areas
- Immuno-oncology