Il23r

Function

Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis (By similarity).

Post-translational modifications

Phosphorylated in response to IL23.

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 2 subfamily.

Tissue Specificity

Expressed by Th1, Th2 and dendritic cells.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein

Alternative names

Interleukin-23 receptor, IL-23 receptor, IL-23R, Il23r

Database links

swissprot:Q8K4B4 entrezGene:209590

Other research areas

• Immuno-oncology